Bitter tasting compounds dilate airways by inhibiting airway smooth muscle calcium oscillations and calcium sensitivity
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چکیده
منابع مشابه
Calcium Hypersensitivity in Airways Smooth Muscle
The isometric tension of anaphylactic guinea pig trachealis muscle preparation was examined at subphysiologic extracellular calcium concentrations, in vitro . Paired observations of control to passively sensitized (egg albumin antiserum) and antigen-challenged muscles (anaphylaxis) were made by exposure to trace Ca++ followed by cumulative Ca++ replacement. Following anaphylaxis, a leftward shi...
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In a variety of smooth muscle cells, agonists activating membrane receptors induce oscillations in the cytoplasmic Ca(2+) concentration via an inositol trisphosphate-activated mechanism. Ca(2+) oscillations participate in the control of cell membrane potential and the tone of smooth muscle. There is evidence that alterations in Ca(2+) oscillations modulate smooth muscle responsiveness.
متن کاملCalcium signaling in airway smooth muscle.
Contractility of airway smooth muscle requires elevation of intracellular calcium concentration. Under resting conditions, airway smooth muscle cells maintain a relatively low intracellular calcium concentration, and activation of the surface receptors by contractile agonists results in an elevation of intracellular calcium, culminating in contraction of the cell. The pattern of elevation of in...
متن کاملPhosphoinositide 3-kinase gamma regulates airway smooth muscle contraction by modulating calcium oscillations.
Phosphoinositide 3-kinase gamma (PI3Kgamma) has been implicated in the pathogenesis of asthma, but its mechanism has been considered indirect, through release of inflammatory cell mediators. Because airway smooth muscle (ASM) contractile hyper-responsiveness plays a critical role in asthma, the aim of the present study was to determine whether PI3Kgamma can directly regulate contractility of AS...
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Phosphoinositide 3-kinase (PI3K ) has been implicated in the pathogenesis of asthma, but its mechanism has been considered indirect, through release of inflammatory cell mediators. Because airway smooth muscle (ASM) contractile hyper-responsiveness plays a critical role in asthma, the aim of the present study was to determine whether PI3K can directly regulate contractility of ASM. Immunohistoc...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2014
ISSN: 0007-1188,1476-5381
DOI: 10.1111/bph.12460